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interpack 2023

Apr 11, 2023

The demand for pharmaceutical products is increasing worldwide, with more and more medications being launched onto the market in ever shorter periods of time. Last year alone, turnover in the German pharmaceutical market – the largest in Europe and the fourth largest worldwide – was around 53.6 billion euros.

According to Statista, the volume has more than doubled in the last 15 years, and almost 100 billion counting units (tablets, sachets, injections, etc.) were sold at last count. They all have to be packaged hygienically and safely, meeting strict legal requirements. This places high demands on packaging materials, filling processes and packaging machines.

The COVID-19 pandemic drove home how important protective packaging is for vaccines, medications, disinfectants and other medical products. Using the example of COVID vaccines, we have seen that developing a vaccine is not enough. Numerous players along the entire supply chain had to work well together to ensure that millions of people were protected from the virus. Billions of glass vials for the vaccine were needed, as well as special cold boxes for transport and special freezers for storage.

When the packaging world meets in Düsseldorf, Germany, for interpack from May 4 – 10, 2023, it will also be about innovations in manufacturing, packaging and logistics of pharmaceutical products, including new solutions to the problem of product piracy. The pharmaceutical industry is affected by counterfeiting like no other. The lucrative business with counterfeit medications, which in the best-case scenario only contain fewer active ingredients but can also be laced with unknown substances that are harmful to health, has increased again with the growing online trade. The World Health Organization estimates that more than half of the medications bought online from illegal websites are counterfeit. The estimated market value of counterfeit medications is around 75 billion US dollars per year.

Counterfeit protection through security features

In addition, global supply chains are becoming increasingly complex. Active ingredients are often produced in one country, processed and packaged in another and finally distributed and marketed across borders. The European legislator therefore took up the fight against counterfeit medications years ago with EU Directive 2011/62/EU. The directive, which started in 2019, specifies a number of safety features for prescription medications. For example, each medication package must be labelled with a Unique Serial Code (USC) in combination with the article number (GTIN), the lot number (LOT), the expiry date (EXP) and the name of the manufacturer. All information is encoded in a 2D data matrix code, which is then printed in plain text on the packaging with a certain minimum print quality. In addition to the unique code, each package must carry tamper-evident features.

Companies such as interpack exhibitor Bluhm Systeme have been developing coding and labeling solutions for pharmaceutical packaging that comply the EU directive for counterfeit-proof packaging for years. This includes various labeling solutions such as laser or inkjet coders, thermal transfer printers, labeling systems and the appropriate software. For example, the Integra One inkjet labeler developed for drug coding prints unique identification codes, barcodes or data matrix codes on a wide range of pharmaceutical packaging.

UV laser marking is also a proven labeling solution. Domino has introduced a new UV laser system in 2022 that is suitable for marking plastics as well as current sustainable packaging materials, including recyclable, flexible mono-material films. The system can be used to mark both white and colored substrates without compromising the barrier properties of the material. Due to a photochemical reaction, the new marking laser does not rely on laser-activating pigments or additives or specially prepared coding fields.

Labels – more than just stickers

Anti-counterfeiting measures can also be security labels with first opening indication and integrated overt, covert and digital anti-counterfeiting features that irreversibly indicate a tampering attempt. Void seals, which leave visible effects when the label is first removed, are ideal for outer packaging. Various security features are often combined or supplemented with additional functions. In addition, digital labels with NFC technology and track & trace systems ensure the complete traceability of a pharmaceutical product.

Labels are an important component of pharmaceutical packaging and serve not only to protect against counterfeiting. Depending on the application on primary packaging such as bottles, blisters, syringes and vials or on secondary packaging such as folding boxes, they have to meet a wide variety of requirements: They carry general information, guarantee first-opening protection or can be partially detached to be pasted into patient records or vaccination cards. Multipage labels can also accommodate large amounts of information; they are often a combination of label and package insert. And for products that need to be refrigerated, temperature-resistant labels are needed to ensure good legibility during storage and transport.

Increasingly automated

As safety is paramount for pharmaceutical products, the requirements for packaging machinery are also high. Machine manufacturer R.Weiss, for example, uses modular picker lines in which Delta robots pack products at top speed. For Siemens Healthineers, the company recently developed an intelligent UniRob turnkey system for packaging diagnostic products that automates the process of manually loading folding cartons. In the process, multipacks in different pack sizes are now also placed in environmentally friendly cardboard inlays, which replace the plastic previously used. A six-axis robot sucks the blanks from the magazine, unfolds them and inserts them into the carrier conveyor, which can be flexibly and fully automatically adapted to the respective formats.

Multivac has introduced a new carrier system in the Healthcare sector that ensures controlled, gentle product transport from pre-filled glass or plastic syringes to the packaging machine. For this purpose, the syringes are separated in an upstream process and placed in an oriented position in a workpiece carrier. At the packaging machine, a robot then takes them from the carriers and places them individually or pre-grouped into the packaging cavities. The packs are checked for completeness using a vision system from Multivac Marking & Inspection. Even at high throughput, it checks whether the individual products are correctly placed in the designated cavities. If they are not, the corresponding pack is automatically ejected.

Sustainable pharmaceutical packaging

The pharmaceutical industry is still reluctant to use recyclable materials. However, consumers today also expect more commitment to sustainability from this industry. Pharmaceutical packaging manufacturers are already one step ahead and have already developed numerous recyclable solutions for the primary and secondary packaging of medications. Last year, for example, the presentation of a recyclable paper blister was a sensation, and a recyclable monomaterial barrier tube in pharmaceutical quality was awarded a packaging award. Recently, a tubular film made from the bio-based polymer PLA was launched on the market that is industrially compostable and can be used as a sterile barrier system for diagnostic flow-pack applications.

The interpack trade fair in Düsseldorf, Germany, will show what other modern solutions the industry has in store. From May 4 – 10, 2023, interpack visitors will be able to get information about innovative packaging and process developments for the pharmaceutical industry, especially in Halls 15 to 17. For more information, visit

Doris Bünnagel has been working for German packaging media for over 20 years after studying natural sciences at the University of Cologne and training as a journalist at the Institute of German Business.

Counterfeit protection through security features Labels – more than just stickers Increasingly automated Sustainable pharmaceutical packaging